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Effects of quercetin on polychlorinated biphenyls-induced liver injury in rats. University of Leon. Introduction: Polychlorinated biphenyls PCBs , used as pesticides in agriculture, can lead to irreversible injuries in living organisms, particularly in liver. Oxidative stress has been implicated in the liver pathogenesis induced by different molecules, including PCBs. It has been demonstrated that quercetin, an antioxidant flavonoid found in the diet, exhibits a potent antioxidant effect in different liver pathologies. Objective: To evaluate oxidative stress caused by PCBs in liver and the antioxidant activity of quercetin. The histological analysis showed damage to hepatocytes in PCBs, but quercetin was able to afford protection against such damage.
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